Biometric Access Through USB Key for Desktop Application

I am seeking direction on how to set up my desktop application to be unlocked using a USB Key.

Any articles or direction would be greatly appreciated.

You mean, USB Key = FIDO2 key? Are you running Windows?

The only way to “unlock” the desktop, AFAIK, are master password, PIN, or OS “biometric” support. You can’t unlock with either make-your-own USB key, or FIDO2 USB key, etc.

You can use FIDO2 USB key for “logging” into the desktop as a 2FA method. That’s about it.